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Antibody-drug conjugates (ADCs): Navigating Four Pillars of Safety, Development, Supply Chain and Manufacturing Excellence
Our highly skilled process chemists and analytical scientists possess over a decade of experience developing and scaling up processes for linking small molecule payloads to polymers in support of antibody-drug conjugates (ADCs), polymer drug conjugates and other drug delivery applications.
- Experience from early development through commercial GMP manufacturing
- Highly potent compounds – SafeBridge® category 4
- Experience with multiple linker-payload systems and diverse types of polymers – PEGs, polyesters, polyamides, polysaccharides, polypeptides
- Large column chromatography
- Determination and control of molecular weight – MALS/GPC/SEC techniques to determine the molecular weight distribution
- Diafiltration/tangential flow filtration (TFF) /reverse osmosis
- Lyophilization
