Flash Chromatography in Clinical ADC Payload-Linker Production by Will Sanders

In this talk, Veranova’s Global VP, Chemical Development Operations, Will Sanders, explores the critical role of flash chromatography in the development and clinical advancement of increasingly complex ADC payload-linkers.

As linker architectures evolve, incorporating greater polarity, stereochemical complexity, hydrophilic shielding, and novel trigger mechanisms, purification has become a major bottleneck in speed, cost, and scalability.

Drawing on extensive industrial and academic experience, Will challenges the default reliance on preparative HPLC and highlights flash chromatography as a faster, more economical, and highly scalable alternative for early clinical production.

This talk compares flash chromatography and prep HPLC across key dimensions including throughput, solvent usage, cost, safety, and GMP suitability, and demonstrates how flash methods can be reliably developed and scaled for kilogram-scale manufacturing.