Understanding the formation of cocrystals

Within the chemical industry, interest in multicomponent systems such as salts, solvates, and cocrystals lies primarily in their ability to change the physicochemical properties of solids without having to inherently change their molecular structure. By incorporating guest molecular species into the solid form, the intermolecular interactions within the crystalline lattice can be altered. This in turn can provide increased solubility, bioavailability, stability, purity (chemical and chiral), or improved processability compared to the freeform entity only. Despite the possibilities offered by cocrystal development, the response from industry until recently has been moderately low. The slow uptake has been attributed to regulatory ambiguity, and difficulties with cocrystal formation during scale-up, amongst other challenges.



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