Our highly skilled process chemists and analytical scientists possess over a decade of experience developing and scaling up processes for linking small molecule payloads to polymers in support of antibody-drug conjugates (ADCs), polymer drug conjugates and other drug delivery applications.

  • Experience from early development through commercial GMP manufacturing
  • Highly potent compounds – SafeBridge® category 4
  • Experience with multiple linker-payload systems and diverse types of polymers – PEGs, polyesters, polyamides, polysaccharides, polypeptides
  • Large column chromatography
  • Determination and control of molecular weight – MALS/GPC/SEC techniques to determine the molecular weight distribution
  • Diafiltration/tangential flow filtration (TFF) /reverse osmosis
  • Lyophilization
Scientist at Isolator

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